Health as a microbial ecology evolution of gut-biocenosis

Health as a microbial ecology evolution of gut- biocenosis

FUTURE HORIZON of NUTRITION

This European project project must be outlined as a modern nutritional prevention research that pursues the saying quoted of Hippocrates : “Let food be thy medicine and medicine be thy food”

The composition and activity of the gut microbiota co-develop in symbiosis with the Human host from birth and adapting at the different stages of life to ageing. The complex interactions depends on the host genome, high quality of nutrition, and active life-styles. The gut microbiota of the gastro intestinal tract (GI) is involved in the regulation of multiple host-metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling to get a control of metabolic functioning of body and brain. The progressive lose of symbiotic inter-playing activities (Dysbiosis) produces auto-immune-inflammatory axes with living organs connecting physiologically the gut, to liver, muscle, and brain. A deeper understanding of these axes for the prevention of dysbiosis is the main goal of the FUTURE HORIZON OF NUTRITION, EUROPEAN PROJECT, addressed to optimizing preventive therapeutic strategies to maintain an metabolic symbiosis of a healthy gut microbiota and to combat disease and improve Human Health.

FUHONU project will develop a multidisciplinary international Nutrition-research into the Human Microbiome leading to a prevention of the Human Health for going beyond the actual situation of Microbiome studies. The main purpose of the FUHONU project (FUTURE HORIZON OF NUTRITION) coordinated by the University of Florence and promoted by EGOCREANET x//CERA), is focused to understand how the nutritional factors affect the microbiome in relation to the prevention of metabolic and immunologic diseases in the period of time that goes from birth to old age. In addition, the project aims to study the influence of changes in the metabolism of the microbiome on the brain development and on the human behavior that occur during the progression of elderly.

The gut microbiome works as a “primary metabolic organ” that characterize the individual functional and distinctive symbiotic activities between genoma and microbioma. It has been amply demonstrated in numerous studies over the last ten years that a total of genes on the human microbiome act as an interface to epigenetic privileged relations that connect in a symbiotic activity our genes to the history of individual environmental exposures. The symbiotic relationship between genoma and microbioma follows the progressive adaptation of gut-microbiome. For instance, we know that two identical twins possess two different microbiome during their life, this because their microbiomes was individually modulated by their dietary and psychology histories.Therefore, the exploration of the relationship between diets and functionality of the microbiome, as primarily metabolic organ, now offers (starting from the knowledge of the actual situation about the argument), the ability to provide new important insights for the overall health of the body and the mind. The research of the Project European Consortium FUHONU, will be dedicated particularly to the dysbiosis as a cause of some physiological and neurological disorders.The dysbiosis influence the metabolic functionality of the microbiome and impact on the whole neurotransmission of both enteric and cerebral communication systems and this interactivity affect the alteration of personality and behavioral and cognitive processes.A better understanding of the nutritional prevention, exerted by appropriate routes of xenobiotic metabolism, aiming to ensure and maintain with the ‘advancing from age’ a HEALTHY GUT microbiome, has important implications for the FUHONU proposal, to improve the effectiveness of health by reducing the risk of physical and psychological diseases, resulting from malnutrition. The ultimate goal it is to get a clear reduction of pharmacological and medical –care costs of the welfare state.

The FUHONU research will be concentrated in the understanding the functionality of Symbiosis of MICROBIOME working in a cooperative coexistence with Human Life. This can be obtained through a comparison to the effects of Dysbiosis that degenerate the healthy gut Microbiome giving rise to the diet related diseases. In this way the FUHONU project will develop a revolutionary approach that is seeing “health as a microbial ecology evolution of gut biocenosis” between gastro intestinal bacteria and humans.

The Dysbiosis provokes changes in the bio-fermentation system of the gut microbiome and some of such metabolites, coming from the change of the gut- fermentation, can be seen as marker-sand signals of human health. Hence a “Healthy Gut Microbiome” can be seen on the basis of a grow up of microbial-flore diversity, that can modulate the enzyme’s reactor efficiency in order to change the risk factors of metabolic and immunologic diseases.The emphasis, of the FUHONU project is to check the diets which should be useful to maintain a proper ecological balance in the gut -microbiome. This because when that balance is disrupted by dysbioses, such as through the use of a powerful, broad-spectrum of antibiotics, there can be serious consequences for a healthy gut microbiome, and also for a degeneration of immunological protection. Therefore the core of the FUHONU project will be the study of diet’s- kits tested to maintain or restore an “Healthy gut Microbiome” in pupils and adult persons (man and women) and to help an active elderly. Those KITS of food and nutraceutical products will be studied and tested to improve some epidemiological-dietary demonstration trials. The confrontation will be made between a Kist’s eating healthy group of persons and other groups of obese people or other groups having for instance inflammatory bowel diseases.With this method of investigation s FUHONU Project will enhanced a good evidence that the microbiome is dynamic and can be manipulated through diets to improve Human Health, and those results are going to be considered to improve next generation of higher quality of fortified foods and innovative nutraceutical or pre/probiotics products.

Finally, the complex challenge of the project FUHONU is largely “cultural”, because the FUHONU project needs to be addressed by large groups of multidisciplinary research that includes not only those studying the intestinal microbial ecology such as gastroenterologists, but also nutritionists, neurologists, biologists and chemical researchers of metabolomics and genetics, …. those researchers together need to be able to share their approaches and experimental and cognitive research plans, into an extended and controlled epidemiological dietary study that will be defined and planned by ISPO Tuscany Region.

In conclusion this complex INNOVATION of FUHONU international project, requires not only overcome the traditional disciplinary academic boundaries, but also to take into account how different diets related to the various food traditions and cultural (lifestyles) in Europe and in the world, can get a similar personalized healthy gut symbiosis. This endeavor of FUHONU project may be studied precisely because the personalized symbiosis between genoma and microbioma could play a major role in Human Health research and lead to a Revolution in Human Health’s prevention for shaping the characteristics of personal health and individual behavior as a consequence of evolutionary factors that affect the individual history of the composition of the personalized microbiome.

Bibliography on line:

https://www.facebook.com/groups/195771803846822/ ; http://www.genome.gov/27549400

http://mpkb.org/home/pathogenesis/microbiota ; http://www.ispo.toscana.it/

http://onlinelibrary.wiley.com/doi/10.1111/j.1753-4887.2012.00499.x/full

 

Paolo Manzelli: born in Terni(It)-25th/06/1937, Graduate in Chemical-Physic (Florence University 1967),

Pmanzelli.lre@gmail.com

President of EGOCREANET R&D (No for profit Association) c/o Business Incubator of Florence University.

Web: http://www.egocreante.it; http://www.edscuola.it/lre.html; http://www.edscuola.it/lre.html;
http://gsjournal.net/Science-Journals-Papers/Author/742/paolo,%20manzelli; dabpensiero.wordpress.com/; www.globale.it

 

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